Changes in superoxide dismutase activities and concentrations and myeloperoxidase activities in leukocytes from patients with diabetes mellitus
K Uchimura, A Nagasaka, R Hayashi, M Makino… - Journal of Diabetes and …, 1999 - Elsevier
To investigate whether the two free-radical scavengers, Cu, Zn-and Mn-superoxide
dismutase (SOD), are changed in leukocytes of diabetic patients, and the alteration of these
enzymes correlates with the diabetic state, we measured the activity and concentration of
these enzymes in leukocytes from diabetic patients. Both Cu, Zn-SOD and Mn-SOD activities
in neutrophils and lymphocytes were significantly lower in patients with non–insulin-
dependent diabetes mellitus than in healthy controls. The concentrations of these enzymes …
dismutase (SOD), are changed in leukocytes of diabetic patients, and the alteration of these
enzymes correlates with the diabetic state, we measured the activity and concentration of
these enzymes in leukocytes from diabetic patients. Both Cu, Zn-SOD and Mn-SOD activities
in neutrophils and lymphocytes were significantly lower in patients with non–insulin-
dependent diabetes mellitus than in healthy controls. The concentrations of these enzymes …