Type II collagen—induced auricular chondritis
WJ Mccune, AL Schiller… - … : Official Journal of …, 1982 - Wiley Online Library
WJ Mccune, AL Schiller, RA Dynesius‐Trentham, DE Trentham
Arthritis & Rheumatism: Official Journal of the American College …, 1982•Wiley Online LibrarySensitization to type II collagen induced inflammatory destruction of elastic ear cartilage, as
well as arthritis, in Sprague—Dawley rats. This auricular lesion morphologically resembled
relapsing polychondritis in humans. Moreover, in the experimental model, as has been
reported in human disease, extraarticular chondritis occurred in the context of immunologic
sensitivity to native type II collagen. These similarities suggest that type II collagen‐induced
auricular chondritis may provide insights about the pathogenesis of relapsing polychondritis.
well as arthritis, in Sprague—Dawley rats. This auricular lesion morphologically resembled
relapsing polychondritis in humans. Moreover, in the experimental model, as has been
reported in human disease, extraarticular chondritis occurred in the context of immunologic
sensitivity to native type II collagen. These similarities suggest that type II collagen‐induced
auricular chondritis may provide insights about the pathogenesis of relapsing polychondritis.
Abstract
Sensitization to type II collagen induced inflammatory destruction of elastic ear cartilage, as well as arthritis, in Sprague—Dawley rats. This auricular lesion morphologically resembled relapsing polychondritis in humans. Moreover, in the experimental model, as has been reported in human disease, extraarticular chondritis occurred in the context of immunologic sensitivity to native type II collagen. These similarities suggest that type II collagen‐induced auricular chondritis may provide insights about the pathogenesis of relapsing polychondritis.
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