Genetic models of obesity and energy balance in the mouse
SW Robinson, DM Dinulescu… - Annual review of …, 2000 - annualreviews.org
SW Robinson, DM Dinulescu, RD Cone
Annual review of genetics, 2000•annualreviews.org▪ Abstract Obesity is a health problem of epidemic proportions in the industrialized world.
The cloning and characterization of the genes for the five naturally occurring monogenic
obesity syndromes in the mouse have led to major breakthroughs in understanding the
physiology of energy balance and the contribution of genetics to obesity in the human
population. However, the regulation of energy balance is an extremely complex process,
and it is quickly becoming clear that hundreds of genes are involved. In this article, we …
The cloning and characterization of the genes for the five naturally occurring monogenic
obesity syndromes in the mouse have led to major breakthroughs in understanding the
physiology of energy balance and the contribution of genetics to obesity in the human
population. However, the regulation of energy balance is an extremely complex process,
and it is quickly becoming clear that hundreds of genes are involved. In this article, we …
▪ Abstract
Obesity is a health problem of epidemic proportions in the industrialized world. The cloning and characterization of the genes for the five naturally occurring monogenic obesity syndromes in the mouse have led to major breakthroughs in understanding the physiology of energy balance and the contribution of genetics to obesity in the human population. However, the regulation of energy balance is an extremely complex process, and it is quickly becoming clear that hundreds of genes are involved. In this article, we review the naturally occurring monogenic and polygenic obese mouse strains, as well as the large number of transgenic and knockout mouse models currently available for the study of obesity and energy balance.
Annual Reviews